Editorial: Early Metabolic Drivers of Neurodevelopmental Disorders: Potential Pathways to Early Detection and Novel Interventions
Richard E. Frye MD, PhD
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders
Frye, R., Rossignol, D. Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders. Pediatr Res 69, 41–47 (2011).
Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy
Rossignol, D.A., Frye, R.E. Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder Using Magnetic Resonance Spectroscopy. J Autism Dev Disord 42, 640–642 (2012). https://doi.org/10.1007/s10803-011-1276-z
Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Rossignol, D., Frye, R. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry 17, 290–314 (2012). https://doi.org/10.1038/mp.2010.136
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder
Frye, R., Melnyk, S. & MacFabe, D. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Transl Psychiatry 3, e220 (2013). https://doi.org/10.1038/tp.2012.143e
Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease
Frye, R., DeLaTorre, R., Taylor, H. et al. Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry 3, e273 (2013). https://doi.org/10.1038/tp.2013.51
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome
Richard E. Frye, Shannon Rose, John Slattery & Derrick F. MacFabe (2015) Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome, Microbial Ecology in Health and Disease, 26:1, DOI: 10.3402/mehd.v26.27458
The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder
Delhey, L.M.; Nur Kilinc, E.; Yin, L.; Slattery, J.C.; Tippett, M.L.; Rose, S.; Bennuri, S.C.; Kahler, S.G.; Damle, S.; Legido, A.; Goldenthal, M.J.; Frye, R.E. The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder. J. Clin. Med. 2017, 6, 18. https://doi.org/10.3390/jcm6020018
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Today’s complex disorders (Autism, Lyme, PANS, COVID etc) require a new understanding of the role inflammation, toxins, mitochondrial dysfunction etc are playing. Today’s patients need physicians to obtain new strategies, new diagnostic tools, & new perspectives. MAPS delivers these from leading clinicians & researchers. MAPS takes today’s complex health issues & provides a comprehensive path for clinicians to follow for successful outcomes. MAPS teaches tomorrow’s medicine today. Be part of the future – attend MAPS!
