A Mitochondrial Supplement Trial in Autism – A Research Update from Dr. Richard Frye
Dr. Richard E. Frye walks through a double-blind, placebo-controlled crossover trial of a mitochondrial supplement in children with autism. Paper: Hill et al., "A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism," IJMS 2025.
How Gut Bacteria Talk to Mitochondria – A Research Update from Dr. Richard Frye
Dr. Richard E. Frye walks through a new review of how gut bacteria affect mitochondria, the structures that make energy inside nearly every cell. Paper: Frye & Rossignol, "Mechanistic Pathways Linking Gut Microbial Metabolites, Microbial Structural Products, and Host-Microbe Co-Metabolites to Mitochondrial Function," Gut Microbes 2026.
A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications
Richard E. Frye MD, PhD
Editorial: Early Metabolic Drivers of Neurodevelopmental Disorders: Potential Pathways to Early Detection and Novel Interventions
Richard E. Frye MD, PhD
Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach
Rossignol, DA, Frye, RE. Autism Science Digest: The Journal of Autismone. 2011. pp. 21-27.
Mitochondrial Dysfunction in Autism Spectrum Disorder
Frye, RE. The Autism File: Biomedical Update. 2015. pp. 28-34.
Developmental regression and mitochondrial dysfunction in a child with autism
Poling, J. S., Frye, R. E., Shoffner, J., & Zimmerman, A. W. (2006). Developmental regression and mitochondrial dysfunction in a child with autism. Journal of child neurology, 21(2), 170–172. https://doi.org/10.1177/08830738060210021401
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders
Frye, R., Rossignol, D. Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders. Pediatr Res 69, 41–47 (2011).
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